About

MHCXGraph is a Python package for detecting potential T cell receptor cross-reactivity based on peptide–MHC structures.

Issues

MHCXGraph package uses GitHub for project management. Please help us by reporting any problems or requests on the Issues page. Only make sure the bug or request has not already been reported. Click on “Search” and enter some keywords to search.

Thank you for helping us improve MHCXGraph!

Scientific team

MHCXGraph was developed by:

  • Carlos D. M. S. Simões [1, 2]

  • Rocio L. B. R. Maidana [1]

  • Samuel C. Assis [1, 2]

  • João V. S. Guerra [1]

  • Helder V. Ribeiro-Filho [1]

[1] Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials (CNPEM).

[2] Graduate Program in Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, São Paulo, Brazil

If you have any further questions, inquires or if you wish to contribute to MHCXGraph project, please contact us at helder.ribeiro@lnbio.cnpem.br.

Citing

If you use MHCXGraph in your reserach, please cite the following references:

  • (manuscript in preparation)

Funding

This study was supported by the Serrapilheira Institute (grant number Serra–R-2401-47149). This study was financed, in part, by the São Paulo Research Foundation (FAPESP), Brasil, according to the following grants: #2024/12890-5, São Paulo Research Foundation (FAPESP) (to H.V.R.F); #2025/19395-2, São Paulo Research Foundation (FAPESP) (to R.L.B.R.M.); #2025/00373-9, São Paulo Research Foundation (FAPESP) (to C.D.M.S.S); #2024/20196-1, São Paulo Research Foundation (FAPESP) (to S.C.A).

The opinions, hypotheses, and conclusions or recommendations expressed in this material are the responsibility of the author and do not necessarily reflect the views of FAPESP. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

License

The software is licensed under the terms of the GNU General Public License version 3 (GPL3) and is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details.